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O is a highly reactive radical that does significant intracellular damage

GSH the body's most abundant intracellular antioxidant (non-enzyme), plays a vital role in combating oxidative stress and is known to decrease with aging

Chromosome 21 overexpression leads to alterations in genes encoding interferon receptors, proinflammatory cytokines, and oxidative stress modulators such as SOD1 71 , creating an immunometabolic environment that is both permissive to microbial imbalance and vulnerable to its consequences

Oral glutathione has significantly lower bioavailability because it is partially broken down during digestion

Begum AN, Jones MR, Lim GP, et al