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Second, the -glutamylcysteine product is coupled to glycine via GSH synthetase (GSS) to produce GSH or reduced GSH ( via GSH-dependent peroxidase-catalyzed reactions ( T2DM is a chronic metabolic disease characterized by hyperglycemia, prolonged elevated levels of glucose, and insulin resistance

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However, cystine starvation alone did not increase either soluble or lipid ROS in HepG2 cells (Fig

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