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Pre-training administration (3045 minutes before exercise) amplifies fat oxidation during the workout but may reduce strength performance due to competing metabolic demands
While cross-sectional studies show correlations between circadian disruption and age-related diseases, we need more longitudinal studies to determine if circadian improvements can delay the onset of those diseases
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Pioglitazone has demonstrated efficacy but carries risks of weight gain, fluid retention, heart failure, and bone fractures
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