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In addition, weight loss is associated with a reduction in resting energy expenditure due to changes in body composition, so-called metabolic adaptation, which has also been shown to be associated with weight regain [47]

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Discovery and development of dipeptidyl peptidase-4 inhibitors Dipeptidyl peptidase-4 inhibitors (DPP-4 inhibitors) are enzyme inhibitors that inhibit the enzyme dipeptidyl peptidase-4 (DPP-4)