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In the STEP 4 trial, participants who had already tolerated a 20-week run-in found continued treatment at the maintenance dose well tolerated

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Safety Profile of Combination Therapy The safety profile of combined SGLT2i and GLP-1RA therapy is broadly consistent with the known adverse effects of each class, without evidence of novel or synergistic toxicity [11, 26,27,28,29,30]

These brain regions serve as the body chemoreceptor trigger zone, the vomiting center

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