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Efficacy Results of a SURPASS open-label, phase III trial, published in 2021, demonstrated tirzepatides superior glycaemic efficacy and weight reduction compared with existing GLP-1 receptor agonists, including semaglutide 6
In the subsequent double-blind period, 60.3% of participants continuing tirzepatide and 55.8% of those switched to placebo reported at least one adverse event, with gastrointestinal disorders more prevalent in the tirzepatide group
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Comparison of kidney transcriptomic profiles of early and advanced diabetic nephropathy reveals potential new mechanisms for disease progression
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