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Administration of peptides with permeation enhancers, which transiently alter epithelial tight junctions to increase permeability, has been the most studied approach

38,238,243 Besides, the oscillation activation of SIRT1 also regulates the circadian dynamics via deacetylation of the core clock repressor PER2 K680 and mixed-lineage leukemia 1 (MLL1), thereby controlling rhythmic chromatin property and the activity of BMAL1: CLOCK complex

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