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Third, efforts were made to minimize potential bias due to heterogenous medication adherence in real-world patients, namely (1) the study cohort was restricted to include only stable users of study drugs to eliminate the potential confounding effect from the short-term use or non-adherence of study drugs and (2) sensitivity analyses were performed based on the AT scenario to estimate treatment effectiveness, with patients who discontinued or switched study drugs censored to corroborate our base-case analysis results based on the ITT scenario
This apparent contradiction highlights the complex and adaptive nature of cellular signaling and compensatory mechanisms under oxidative stress and urges researchers to pay attention to the downstream regulation of GLP-1 (fibroblast growth factor 21 in this context) when developing GLP-1RAs medication
everything else is harder than it should be
37 , W202W208 (2009)
Presented for research literature review only Sun M et al
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