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(2021) 46:e13635
Additionally, the NNMT substrate nicotinamide 12 is metabolized by the microbiome 56,57 , and thus NNMTi may modulate substrate availability, potentially influencing microbial metabolic capacity to drive the NNMTi-mediated weight loss
It is deliberately membrane-permeable, which is what lets it get inside cells and act on an intracellular enzyme
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