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Tirzepatide versus insulin glargine as second-line or third-line therapy in type 2 diabetes in the Asia-Pacific region: the SURPASS-AP-Combo trial
The primary outcome was MACE, a composite of myocardial infarction, stroke, and all-cause mortality
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Conclusion This study demonstrates that atorvastatin (ATO) disrupts hepatic redox homeostasis and antioxidant defenses, leading to mitochondrial dysfunction, activation of apoptotic pathways, and functional impairment of hepatic CYP3A1 activity, with associated hepatic alterations
J.CarrollJ
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