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They are now commonly used when: Metformin alone is no longer enough Weight gain is contributing to worsening glucose control There is a need to minimise hypoglycaemia risk Someone has existing cardiovascular disease or multiple risk factors For many people, GLP-1 therapy can delay or reduce the need for insulin, or allow insulin doses to be kept lower and safer
This is especially important as formal exercise represents a small fraction of total daily activity for most people
More draws means a thinner needle
Not intended for use by pregnant or nursing women
FGF21 normalizes plasma glucose in mouse models of type 1 diabetes and insulin receptor dysfunction
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