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## After First Use: The 56-Day Window Once you break the seal on a semaglutide pen or puncture a vial with a needle, a countdown begins

Side effects do tend to be more intense right after the weekly shot and whenever your dose goes up, so after you settle in at your final dose level, the side effects may dissipate or linger at a lower and more tolerable level, Kushner says

Ley RE, Turnbaugh PJ, Klein S, Gordon JI

3A, Table S2)

Regarding the latter, there are ongoing clinical trials to examine tirzepatides applicability to other conditionspediatric obesity, kidney disease, and more as well as how the compound interacts with other drugs