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Survodutide is a concrete bet on that principle, and the reason it is studied so intensively is that the bet is testable: if the glucagon axis truly adds something, it should show up as extra weight loss, extra liver-fat reduction, and a distinct safety signature relative to GLP-1 alone
This rapid clearance contributes to the favorable safety profile, as the compound itself does not accumulate in tissues
Ding et al
Longer trials are needed for researchers targeting alterations in body composition or other GH-associated advantages in their subjects
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