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No prospective studies have been conducted in humans in controlled circumstances to demonstrate whether CYP450 polymorphisms lead to an increase or a decrease in paracetamol oxidation nor have there been studies demonstrating that CYP450 polymorphisms in humans increase or decrease the risk of paracetamol toxicity before or after an overdose
10.1007/s10555-010-9246-z 66 Tekeli
T., Sjoholm, A
