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Mechanisms of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2093, and BIA 2024

Chronic low-grade inflammation, as observed in aging, estrogen deficiency, and autoimmune disorders such as rheumatoid arthritis, exerts a negative regulatory effect on bone cells through continuous cytokine release, while oxidative stress further exacerbates cellular damage and signaling pathway disruption via the accumulation of ROS (34)

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GSH deficiency on hepatocyte epigenetic modifying enzymes Hepatocytes treated with GCLC siRNA showed elevated Dnmt, Tet2, and Tet3, but Tet1 was downregulated, and there was no change in Tdg mRNA expression (Fig