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The most dominant metabolites are Lys-lys, Isohexanal, Palmitic acid, Leu-val and 20-Deoxycytidine (75)
This tripeptide serves as the master regulator of cellular redox homeostasis and functions as a critical cofactor in numerous enzymatic reactions essential for life
The combination of optimal substitutions at N-2, C-3, C-6, and N-7 as discussed above is epitomized by Compound 1 with a PDE1 Ki of 58 picomolar, which is over 100-fold more potent than other derivatives
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PMID: 33996787
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