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REDEFINE 1 randomized participants across four arms the cagrilintidesemaglutide combination, semaglutide 2.4 mg alone, cagrilintide 2.4 mg alone, and placebo so the two monotherapies were assigned within one study, even though the trials primary comparison was the combination against placebo

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The authors concluded that supplementation of HA to collagen did not improve various skin parameters, and therefore, the dermal benefits of the HA active ingredient could not be confirmed in this study [53]

& Leeuwenburgh, C