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First, a substantial portion of the mechanistic and translational data derives from preclinical studies or small human cohorts, which may not fully capture understudied aspects of aging that vary across populations
CTL: cytotoxic T lymphocyte
A meta-analysis of five trials in participants with either impaired fasting glucose, type 2 diabetes mellitus, or nonalcoholic steatohepatitis found evidence of an improvement in insulin resistance with supplemental L-carnitine compared to placebo (43)
In addition, the NMF levels were increased at 12 weeks compared with placebo-control levels
Higuchi, R
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