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Glutamate modulators for treatment-resistant OCD: Early-phase studies on riluzole and memantine which target the glutamate system are showing promise as augmentation strategies for individuals who do not respond adequately to SSRIs alone

The FDA approves testosterone replacement therapy only for men with diagnosed hypogonadism causing abnormally low testosterone levels, not for age-related testosterone decline

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This pattern has led obesity medicine experts to reconceptualize GLP-1 therapy as chronic maintenance treatment rather than a temporary intervention