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Oral administration in systemic research For systemic endpoints (tendon, ligament, muscle, cardiac), oral administration is pragmatically useful when: Repeated parenteral injections are impractical for the model A translational research question addresses oral route viability Drinking-water dosing allows long-duration protocol administration For foundational preclinical work aimed at mechanism characterisation or replication of flagship studies, parenteral routes remain the standard
Sigmoidoscopy or Colonoscopy: These procedures allow for a more comprehensive examination of the colon and rectum, particularly if bleeding is present
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This formulation allows the solution to remain usable for multiple withdrawals over a defined period when handled properly under aseptic laboratory conditions
McGarry, J
