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When flying domestically, pack compounded semaglutide in your carry-on bag (never checked luggage, where temperatures may fluctuate excessively)
Heres what typically gets tested: A1C (hemoglobin A1C): Shows average blood sugar over the past 23 months, helping identify prediabetes or diabetes that could affect how GLP-1 medications work
Contraindicated in patients with a history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia Syndromes (MEN 2) Not suitable for individuals with type 1 diabetes or diabetic ketoacidosis Should not be used alongside other GLP-1 receptor medications Gastric emptying may be delayed, requiring caution for procedures involving sedation or general anesthesia due to aspiration risk Use caution in those with a history of diabetic retinopathy 1-3 Consult your healthcare provider if you have a history of pancreatitis, as the medication may increase risk Serious side effects may involve hypoglycemia, kidney issues, or allergic reactions Avoid use during pregnancy and breastfeeding 1 Enhances glucose-dependent insulin secretion Suppresses glucagon secretion Slows gastric emptying Influences brain regions involved in appetite regulation, leading to reduced hunger and caloric intake Improves insulin sensitivity 1-3 Supports weight loss Helps to minimize internal inflammation and improves cardiometabolic health measures 5 Q: How long does it take to see results
A larger February 2025 study analyzing 37.1 million adults with diabetes across 14 databases found semaglutide users had more than 4 times greater risk of NAION compared to non-GLP-1 drugs, with an incidence rate ratio of 1.32
Until recently, the published studies with the new obesity pharmacotherapies have had up to 2 years follow-up [12]
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