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Together, mimetics that modulate mitochondrial metabolism, including AMPK activators (e.g., AICAR and metformin), AdipoRon, PPAR agonists (e.g., GW501516, GW0742, rosiglitazone, pioglitazone, T3D-959, and bezafibrate), cAMP/CREB activators (e.g., forskolin), and mitochondrial protectants (e.g., MitoQ), support the energy-intensive processes of neuronal repair

High-fat diets can also slow the absorption of the drug, making it less effective

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Schmid et al

The gut plays a key role in the development of autoimmunity and Hashimotos, and most people with Hashimotos have some level of intestinal permeability (leaky gut)