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Reductions in HbA 1c and body weight from baseline to week 26 in the overall PIONEER 12 population were greater than those observed at week 26 in the PIONEER 3 trial, which assessed oral semaglutide 3 mg, 7 mg and 14 mg vs sitagliptin 100 mg in a global population across 78 weeks [18]

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Explain to patients receiving JANUMET in combination with these medications the risks of hypoglycemia, its symptoms and treatment, and conditions that predispose to its development [see Warnings and Precautions (5.6)]

Fiber supplements, adequate water intake, and regular physical activity address most cases