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While the mechanistic basis of LPS tolerance has been extensively studied and will not be elaborated here, it is important to note that the dimerization of certain PRRs, such as CLRs and TLRs, can influence ligand binding affinity and modulate immune responses

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It was previously shown that the GLP-1 receptor can control neuronal function in the rat hippocampus by enhancing GABAA signaling through presynaptic and postsynaptic mechanisms (Korol et al., 2015)