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Downregulation of ASS1 caused by promoter methylation increases the susceptibility of tumor cells to PEGylated arginine deiminase (ADI-PEG20) (Table 1), a drug for arginine-deprivation treatment that has been used in clinical trials for a variety of tumors (Delage et al., 2012
Embracing this integrated pathophysiological view is crucial for advancing towards more effective and personalized management strategies for patients with renal anemia
Standard dose ranges from 100-300mcg per injection
Similarly, the expression trends of NOX2 and NLRP3 mirrored Hv1, all showing downregulation
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