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As an inducer of NRF2, DMF could promote SLC7A11 and GPX4 expression, increase cellular cystine and glutathione levels, and mediate anti-oxidative stress effects
However, dosage still increases slowly to minimize side effects, so results are not instant
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According to the Semaglutide Treatment Effect in People with Obesity (STEP) program studies, people with overweight or obesity (without T2DM) who received semaglutide 2.4 mg and underwent lifestyle interventions experienced an average weight reduction of 14.7- 17.4% [116]
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