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The Journal of Biochemistry, 175 (5), 473-480
Choline is a key component of cell membranes and plays a central role in fat transport and liver detoxification pathways
Selenium-dependent glutathione peroxidase (GPx) is the key enzyme responsible for neutralising H2O2 in thyroid tissue, and selenium supplementation has been associated with lower TPO antibody concentrations (Gartner et al., 2002)
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Such molecular changes help to delineate putative mechanisms of action of the di-agonist, with consistent upregulation of factors involved in autophagy, neurotransmitter release, cytoskeletal remodeling, vesicle-mediated transport, and intracellular signaling, and downregulation of pathways related, among others, with oxidative stress, DNA repair and immune system in PWA mice, which showed consistent metabolic improvement at all doses of GLP1/E
