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This medium consisted of RPMI1640, 1 B27 supplement, and 1 ITS, further supplemented with a chemical cocktail named ACDF SV
PP2A dephosphorylates STAT3, reducing its phosphorylation and signaling activity
This creates a shift from chronic inflammation toward resolution and healing
Therapeutic targeting of lactate metabolism The central role of lactate in the metabolic reprogramming of the TME is well-established, acting as both a key byproduct of glycolytic metabolism and a crucial modulator of various cellular signaling networks
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