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Dihexa and its analogs bind with high affinity to HGF, induce Met phosphorylation in the presence of subthreshold levels of HGF, stimulate hippocampal spinogenesis and synaptogenesis equivalent with HGF [84], and promote neurogenesis and cerebroprotection (data in preparation for publication)

FDA GRAS determination (2007): The FDA reviewed AOD-9604's toxicology data and granted Generally Recognized As Safe status for oral use as a food ingredient

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B12 shots commonly cause localized pain, while IV infusions carry additional considerations related to venous access and fluid delivery