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Contraindications include known hypersensitivity to any component of the injection (including cobalt hypersensitivity), a history of severe reactions to thiamine/pyridoxine/cobalamin injections, and Lebers hereditary optic neuropathy (for B12-containing products)

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At the onset of the dark phase, acyl-GIP significantly reduced food intake of DIO Gipr AP-GFP but not Gipr AP-KO animals (Fig