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NK cells can eliminate abnormal joint cells or pathogens via perforin and granzymes, and they secrete cytokines such as IFN- and TNF- to regulate immunity and inflammation (1, 114, 115)
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Lactobacillus fermentum species ameliorate dextran sulfate sodium-induced colitis by regulating the immune response and altering gut microbiota
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The conservative approach: at any dose escalation, implement the step-up protocol proactively (add Miralax the same week you increase dose) rather than waiting for symptoms to become severe
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