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3.2 Relationship between PD-related genes/proteins and ferroptosis PD pathophysiology is significantly influenced by genetic predisposition, with numerous gene loci linked to its development (133)

Commonly used activators include HOBt (1-hydroxybenzotriazole), HBTU (2- (4-hydroxyphenyl) -4,5-dihydro-4-methyl-6-nitroimidazolo [1,2-a] pyridine-3-one), TBTU (2- (2-pyridyldithio) benzotriazole sodium salt), etc

PRPP is an intermediate in purine nucleotide synthesis, generated from ribose 5-phosphate from the pentose phosphate pathway 21

Researchers consistently identify properly designed human clinical trials as the critical next step for establishing clinical relevance

However, these typically go away after a few days