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Patients should not adjust their dose without healthcare provider guidance

Cleveland Clinic explains that muscle tissue is metabolically active, meaning it requires more energy to maintain than fat tissue. When muscle mass decreases, resting energy expenditure may also decrease. Strength training provides a mechanical stimulus that signals the body to preserve muscle tissue during periods of reduced energy intake

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I mean their life lifespan's shorter

On the other hand, the CANVAS program, in which one-third of patients had no prior history of CV events, demonstrated no significant risk reduction in such outcomes [4]