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Based on the efficacy and safety records in T2DM, attention has been given to the repurposing of metformin as part of adjunct therapy for the treatment of cancer, age-related diseases, inflammatory diseases and COVID-19
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If a reactive intermediate is produced faster than glutathione and other Phase II systems can neutralize it, oxidative stress and liver injury may increase
He L, He T, Farrar S, Ji L, Liu T, Ma X
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