Amersi notes that starting low often eliminates the need for aggressive symptom management. Reddit communities are full of users who switched to microdosing after struggling with nausea, constipation, or the sulfur burps that tirzepatide is known for
The action on kidneys appears to be directly through the effects also on renin-secreting cells of the juxta-glomerular apparatus, whose stimulation may lead to increased natriuresis and reduce hyperfiltration, and indirectly by the reduction of angiotensin II levels, the increase in nitric oxide with consequently endothelial vasodilation and the improvement of risk factors of kidney disease (hyperglycemia, hypertension, obesity) (20)
High circulating levels of S100A8/A9 complex (calprotectin) in male Japanese with abdominal adiposity and dysregulated expression of S100A8 and S100A9 in adipose tissues of obese mice
To assess the role of 3-AR in mediating these effects, researchers examined AOD9604 and hGH treatment in 3-KO mice
doi: 10.1111/j.1365-2249.2012.04660.x 81 Carrillo-PalauMHernndez-CambaAHernndez Alvarez-BuyllaNRamosLAlonso-AbreuIHernndez-PrezAet al