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J Clin Invest 117:21552163 Shu L, Matveyenko AV, Kerr-Conte J, Cho JH, McIntosh CH, Maedler K (2009) Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function
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They also show how simulations by USC and others based on clinical trial data with its commiserate exclusions of more complex patients can be entirely off base (or why insurers may limit the populations for an indication)
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