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The article lists fasting glucose above 100 mg/dL as suggesting prediabetes and above 126 mg/dL as indicating diabetes, HbA1c above 5.7 percent and 6.5 percent for the same two categories, and fasting insulin above 12 microunits per milliliter as suggesting resistance

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Thus, in an environment of metabolic overload and insulin resistance, -cells initially activate compensatory pathways to improve insulin secretion, but they eventually initiate several pathological programs that synergistically promote -cell dysfunction and apoptosis [20]