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Clinical trials demonstrate that dual therapy produces HbA1c reductions of 1.5% to 2.0% versus 0.7% to 1.2% with monotherapy alone
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GLSP decreased total cholesterol and triglycerides in diabetic rats as well as attenuated the levels of oxidative stress
Moreover, damage or weakness in the heart muscle itself, disorders of the valves such as stenosis or regurgitation, endocardium, cardiac conduction and rhythm, pericardium, or all of these changes can cause HF [43, 44]
Tirzepatide is more suitable for individuals prioritizing aggressive weight loss (20%+) or those with insulin resistance
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