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Highlights of Prescribing Information - MOUNJARO Highlights of Prescribing Information - OZEMPIC Highlights of Prescribing Information - WEGOVY Highlights of Prescribing Information - ZEPBOUND Once-Weekly Semaglutide in Adults with Overweight or Obesity - The New England Journal of Medicine The Role of Tirzepatide, Dual GIP and GLP-1 Receptor Agonist, in the Management of Type 2 Diabetes: The SURPASS Clinical Trials - Diabetes Therapy Tirzepatide as Compared with Semaglutide for the Treatment of Obesity - The New England Journal of Medicine Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes - The New England Journal of Medicine Tirzepatide Versus Semaglutide on Weight Loss in Type 2 Diabetes Patients: A Systematic Review and MetaAnalysis of Direct Comparative Studies - Endocrinology, Diabetes & Metabolism

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As an illustration of the trial framework not as prescribing guidance the general approach observed involved: A low starting dose (2 mg once weekly) for the initial 4 weeks Incremental increases (for example, to 4 mg, 8 mg, and 12 mg) at approximately 4-weekly intervals, subject to individual tolerability Maintenance doses ranging from 4 mg to 12 mg once weekly across different trial arms These figures are provided solely to describe the research context

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