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Am J Clin Nutr 69 : 467475

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(A) Correlations of 8-OHdG ratio alterations with dermatitis grade over time (Days: D) and radiation therapy dose

GLP-1-based therapies and resmetirom operate through distinct and potentially complementary mechanisms: while resmetirom exerts direct hepatic effects by activating THR- to enhance mitochondrial function, reduce hepatic lipogenesis, and promote lipid oxidation specifically in hepatocytes, GLP-1 RAs and multi-agonists address the upstream metabolic drivers of MASLD including insulin resistance, obesity, and systemic inflammation