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In the late stages of PD, the key molecular pathogenic mechanisms include the misfolding and aggregation of -synuclein, mitochondrial dysfunction, impaired protein clearance (related to inefficient ubiquitin-proteasome and autophagy-lysosomal systems), neuroinflammation and oxidative stress (57)

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Soon after this, in 1788, Thomas Crawley, another English physician, suggested on the basis of one of his clinical cases that diabetes might be linked to damage to the pancreas

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