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The glucagon arm appears to contribute substantively to body-composition outcomes (favouring fat-mass reduction) without offsetting the glycemic outcomes of the GLP-1/GIP arms (PMID 39515565, PMID 40609566)
Recommended for: patients on tirzepatide seeking maximum energy support, patients with documented methylation challenges (MTHFR variants), patients prioritizing cognitive clarity during weight loss
More frequent monitoring of international normalized ratio values may be necessary, particularly during tirzepatide initiation or dose adjustments
was supported by funding from the NIH NIDDK (R01 DK123075, DK125353 and DK046492), the Helmsley Charitable Trust Foundation, investigator-initiated grants from Eli Lilly, Novo Nordisk and Proteostasis, and is a Borden Scholar
& Abo-Zaid, G
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