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Pharmacological activation of hepatic TR potentiates the GLP-1 production Consistently, we found that pharmacological activation of hepatic TR by daily injection of MB07811, a liver-targeted TR-selective agonist, for five days could increase the plasma levels of GLP-1 and insulin, decrease the blood glucose levels, and as well as improve the oral glucose tolerance in MMI mice (Fig
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Zhang, X., Belousoff, M.J., Zhao, P., Kooistra, A.J., Truong, T.T., Ang, S.Y., Underwood, C.R., Egebjerg, T., enel, P., Stewart, G.D., Liang, Y.L., Glukhova, A., Venugopal, H., Christopoulos, A., Furness, S.G.B., Miller, L.J., Reedtz-Runge
The metabolism of glutamate and glutamine in the body is quite complicated because glutamine is produced from glutamate in muscles