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Local ice application typically lasts 15-20 minutes per session, limited to prevent tissue damage from prolonged cold exposure

Statements Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

Add GIP receptor activation, as Tirzepatide does, and you layer in improved insulin sensitivity, enhanced fat metabolism, and what appears to be reduced GI side effects compared to GLP-1-only approaches

Not only that but you end up with increased amounts of oxidants which have been linked to accelerate the ageing process

The damaged proteins accumulate at points, which erupts on the skin's surface as scars, broken capillaries, wrinkles, etc