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Multiple injections are required per treatment area
Therefore, IGF-IR inhibition may paradoxically lead to increased production of IGF1/2 and insulin
The mean percentage of body weight loss at 72 weeks was 15.0% at the lowest dose, and 20.9% in the highest dose cohort (compared to 3.1% in placebo) (NCT04184622)
Acting through complementary pathways simultaneously may produce a more robust and physiologically natural GH pulse than either compound alone
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