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Metformin remains the first-line treatment for most people with newly diagnosed type 2 diabetes because it is safe, effective, and inexpensive

However, the authors note that this prior research on its effects on lipid profiles has yielded inconsistent results

Doctors consider this information when prescribing semaglutide to their patients

The treatment-policy estimand is closer to intention-to-treat: it estimates the effect regardless of whether participants stayed on treatment or used rescue therapies

Cardiovascular outcome trials assess whether weight loss translates to reduced heart attacks, strokes, and cardiovascular deaths