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Benzyl alcohol has been linked to a fatal "gasping syndrome" in newborns, so only preservative-free sterile water for injection should be used in that group
Ipamorelin is more restricted, with stronger selectivity data but weaker body-composition evidence
Adverse events such as diarrhea, constipation, nausea, and vomiting associated with the GLP-1 RAs overlap with those seen with cancer treatments, so the patient who is undergoing treatment with an emetogenic regimen for cancer will likely experience additional weight loss, which can lead to nutritional deficiencies, loss of lean muscle mass, and loss of bone mass
Downstream saturation / spare receptor full physiological response often achieved well below full occupancy because the cells downstream signaling pathway has its own ceiling
