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Although distinct differences exist between methylcobalamin and cyanocobalamin, both have beneficial effects on health and can prevent B12 deficiencies ( In fact, one study found that treating seven B12-deficient people with oral methylcobalamin normalized vitamin B12 levels in their blood within just 2 months ( Similarly, another study showed that taking cyanocobalamin capsules for 3 months also increased vitamin B12 levels in 10 people with pernicious anemia, a condition caused by impaired B12 absorption ( Both types of the vitamin may also provide other health benefits

If you need regular injections of vitamin B12, cyanocobalamin would need to be given once a month, whereas hydroxocobalamin can be given every 3 months

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A Closer Look at B12 Injections for Weight Loss How Do B12 Injections Work for Weight Loss

Implication: This could be promising for individuals with IBD or leaky gut symptoms, though human studies are still needed