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Gradual taper of dose The Approach For patients who want to find the lowest effective dose or to discontinue completely, a gradual taper means stepping the GLP-1 dose down in small, planned increments (typically using the same titration steps as initiation, but in reverse) to test whether benefit can be maintained with less medication or none at all

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2I), which are two essential components of glutamate-cysteine ligase (GCL) involved in GSH synthesis, suggesting a compensatory mechanism under mitochondrial GSH deprivation

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