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Data Animal Data No evidence of teratogenicity or other embryo/fetal toxicity was found when pregnant rats and rabbits were treated orally with amlodipine maleate at doses up to 10 mg amlodipine/kg/day (approximately 10 and 20 times the MRHD based on body surface area, respectively) during their respective periods of major organogenesis
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To realize this potential, a clear clinical translation path is required
Moreover, the combination of aspirin and sorafenib did not cause weight loss, liver injury, or inflammation in the mice [146]
For severe deficiency, clinicians typically prescribe loading doses daily or every other day for one to two weeks followed by monthly maintenance injections
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